De-sexing or spaying and neutering of female and male rabbits is an essential veterinary procedure to ensure your rabbit becomes the best possible indoor companion. Unaltered rabbits are governed by their hormones and can spray urine, exhibit sexually motivated aggression, and females can suffer high rates of reproductive cancers. Spaying or neutering is a generally safe and uncomplicated medical procedure when performed by a vet who has experience with rabbits. See the House Rabbit Society articles below for more information. For a list of local veterinarians who are experienced with rabbits, click the link below.